In an alternate universe, the Justice League is a brutal force that maintains order on Earth. Superman is the son of General Zod, who was rocketed to Earth as a child and raised by a family of Mexican immigrants. Batman is Kirk Langstrom, a scientist who has inadvertently transformed himself into a vampire in an attempt to cure his cancer. Wonder Woman is Bekka, who was the bride of the New God Orion. However, the Justice League's unaccountability is challenged by the world's governments following the suspicious deaths of renowned scientists.
Crime is on the run as the newly formed Justice League keeps Metropolis safe and this makes evil genius Lex Luthor very unhappy. Together with Black Manta, Sinestro and a gang of ruthless recruits, Lex builds his own league and declares them the Legion of Doom. With this super powered team of terror and a plan to attack the top-secret government site, Area 52, can Lex finally be on the verge of victory? Sound the alarm and get ready for the bricks to fly when Superman, Batman, Wonder Woman and the rest of the Justice League face off against the world’s greatest Super-Villains!